Anees Ahmed Mahaboob Ali

Gene-level evolutionary conservation and human constraint decline at comparable rates across the age of onset of Mendelian disease

The paper compares the rate of decline in gene-level evolutionary conservation and human constraint scores with disease onset age across Mendelian diseases.

Attachment site, not linker length, bounds tethered base editor windows

The paper shows that the attachment site, not linker length, determines the activity window of tethered base editors by analyzing geometric models and experimental data.