Edmon Begoli

Diversity and Scale: Genetic Architecture of 2,068 Traits in the VA Million Veteran Program

Population-stratified GWAS of 2,068 traits in 635,969 Million Veteran Program participants, 29% genetically non-European, yields 98,485 associations and 57,601 fine-mapped signals with largely shared cross-population architecture.

Accelerating Genome- and Phenome-Wide Association Studies using GPUs - A case study using data from the Million Veteran Program

This paper optimizes the SAIGE algorithm using GPUs to accelerate GWAS on large datasets, achieving 20x speedup on the Million Veteran Program data.

sciCAN: Single-cell chromatin accessibility and gene expression data integration via Cycle-consistent Adversarial Network

sciCAN integrates single-cell chromatin accessibility and gene expression data using an adversarial network, outperforming existing methods in cross-modal transfer and preserving biological structure in hematopoietic data.