Exploration of the circulating human secretome through protein quantitative trait analysis identifies an association between circulating levels of apolipoprotein L1 and risk of giant cell arteritis
Natalie Chaddock, Michal Zulcinski, Javier J. Martin, Anders Mälarstig, James E. Peters, Mark Martin Iles, Ann Wendy Morgan
This paper identifies a protective association between apolipoprotein L1 polygenic risk scores and reduced risk of giant cell arteritis, supported by Mendelian randomization and pathway analysis.
medRxiv · Jan 19, 2024 · PreprintGenetic & Genomic Medicine