Author

Kalle Leppälä

University of HelsinkiORCID 0000-0002-2304-7595Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Approach:Bayesian inference· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:phylogenetics / evolution· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Andrew H. VaughniD· 1 shared Charlotte LindqvistiD· 1 shared Flavio Augusto da Silva CoelhoiD· 1 shared Michael J. LandisiD· 1 shared Michaela RichteriD· 1 shared Rasmus NielseniD· 1 shared Svend Vendelbo Nielsen· 1 shared Thomas MailundiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 16 mutual co-author links

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1 shared paperGenetics

Andrew H. VaughnORCID

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3 papers

Recent·Most cited

Notes on f4-ratio estimation

Kalle Leppälä

The paper discusses f4-ratio estimation, highlighting its versatility due to the irrelevance of the root and introducing an improved branch statistic for detecting gene flow.

bioRxiv · Dec 24, 2025 · PreprintEvolutionary Biology

Five-leaf generalizations of the D-statistic revealthe directionality of admixture

Kalle Leppälä, Flavio Augusto da Silva Coelho, Michaela Richter, Victor A. Albert, Charlotte Lindqvist

This paper introduces a new family of five-leaf admixture tests called {Delta}-statistics to better determine the directionality of admixture compared to existing methods like DFOIL.

Molecular Biology and Evolution · Sep 20, 2024Peer-reviewedGenetics

Bayesian inference of admixture graphs on Native American and Arctic populations

Svend Vendelbo Nielsen, Andrew H. Vaughn, Kalle Leppälä, Michael J. Landis, Thomas Mailund, Rasmus Nielsen

The paper introduces a Bayesian MCMC method for inferring admixture graphs and applies it to Native American and Arctic populations, finding that the Koryak population, not Saqqaq, is the best proxy for gene flow into Athabascans.

PLoS Genetics · Feb 13, 2023Peer-reviewedGenetics