Partitioning gene-level contributions to complex-trait heritability by allele frequency identifies disease-relevant genes
Kathryn S. Burch, Kangcheng Hou, Yi Ding, Yifei Wang, Steven Gazal, Huwenbo Shi, Bogdan Paşaniuc
The paper partitions gene-level heritability by allele frequency to identify disease-relevant genes with heritability from rare variants, finding 370 gene-trait pairs not detected by existing methods.
The American Journal of Human Genetics · Mar 9, 2022Peer-reviewedGenetics