The endogenous metabolite hypochlorite activates indoleamine 2,3-dioxygenase-1 for catalysis: Functional and mechanistic implications
Setareh Saryazdi, Steven G. Van Lanen
This paper identifies sodium hypochlorite as an endogenous activator of IDO1, revealing a hypohalous acid-dependent catalytic mechanism for L-Trp oxidation.
Angewandte Chemie International Edition · Sep 29, 2026Peer-reviewedBiochemistry