Understanding LRRK2 kinase activity in preclinical models and human subjects through quantitative analysis of LRRK2 and pRab10
Xiang Wang, Elvira Negrou, Michael T. Maloney, Vitaliy V. Bondar, Shan V. Andrews, Manuel Montalban, Ceyda Llapashtica, Romeo D. Maciuca, Hoang Ngan Nguyen, Hilda O. Solanoy, Annie Arguello, Laralynne Przybyla, Nathan J. Moerke, Sarah Huntwork, Anastasia G. Henry
The paper develops and applies quantitative assays to measure LRRK2 and pRab10 levels in cellular models and human subjects to assess LRRK2 kinase activity and its association with Parkinson's disease.
Scientific Reports · Jun 18, 2021Peer-reviewedNeuroscience