Isoform-level analyses of 6 cancers uncover extensive genetic risk mechanisms undetected at the gene-level
Yung-Han Chang, Sean T. Bresnahan, S. Taylor Head, Tabitha A. Harrison, Yao Yu, Chad Daniel Huff, Bogdan Paşaniuc, Sara Lindström, Arjun Bhattacharya
This study identifies genetic risk mechanisms for six cancers by analyzing isoform-level expression data, finding more associations and greater heritability explained compared to gene-level analysis.
British Journal of Cancer · Aug 7, 2025Peer-reviewedGenetic & Genomic Medicine