Biochemical signatures from dried blood spots in untargeted metabolics are influenced by matrix effects
Jan-Clemens Cremer, Viktorija Jurić, Jakob M. Koch, Sabine Scholl‐Bürgi, Daniela Karall, Johannes Zschocke, Markus Andreas Keller
The paper investigates matrix effects on metabolite recovery from dried blood spots (DBS) and shows that despite these effects, DBS can be used for diagnostics with proper validation.
bioRxiv · Jul 22, 2025 · PreprintBiochemistry