The dynamic role of HLA proteins on compositional alterations of T-cell repertoires in inflammatory bowel disease
Evgeniya Lokes, Gabriele Mayr B, Malte Ziemann, Bernd Bokemeyer, Stefan Schreiber, Astrid Dempfle, Kazuyoshi Ishigaki, André Franke, Hesham ElAbd
This study identifies HLA-associated CDR3-QTLs that influence T-cell receptor composition in IBD and healthy controls, revealing disease-specific and universal effects on TRB repertoires.
bioRxiv · Oct 27, 2025 · PreprintImmunology