Read-Consistent Minimum Unique Substrings: A Parameter-Free, Linear-Time Framework for Genomic Sequence Representation
Andrews Frimpong Adu, Elliot Sarpong Menkah, Peter Amoako-Yirenkyi, Samson Pandam Salifu
This paper introduces Minimum Unique Substrings (MUSs) as a parameter-free, linear-time framework for genomic sequence representation, showing improved coverage and resolution compared to fixed-length k-mers.
bioRxiv · May 25, 2026 · PreprintBioinformatics