BioinformaticsbioRxivPreprint
Gene-family-dependent thermodynamic effects of oncogenic mutations on nucleosome-DNA binding stability: a comparative molecular dynamics study across 22 cancer hotspots
Shlomo Freudenberger, Evan Boczko, Sanjay Goel, Radhashree Maitra
This study uses molecular dynamics simulations to analyze thermodynamic effects of 22 cancer hotspot mutations on nucleosome-DNA binding stability across 10 oncogene families, revealing gene-family-dependent trends.
DOI 10.64898/2026.09.28.754892