Pablo Yubero

The limitations of phenotype prediction in metabolism

The paper presents a framework using genome-scale metabolic reconstructions to interpret genotype-to-phenotype associations and identifies limitations in phenotype prediction in metabolism.

Predicting the fitness costs of complex mutations

The paper develops a statistical framework to predict fitness costs of complex mutations by identifying key molecular predictors using RNA polymerase mutations in E. coli.

The impact of global transcriptional regulation on bacterial gene order

The paper quantifies how global transcriptional regulation affects gene expression across 700 genes in E. coli and shows that gene position near the origin of replication correlates with sensitivity to transcriptional resources.