Author

Caroline Lohoff

Heidelberg UniversityORCID 0000-0002-3084-8833Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:Bayesian inference· 1 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Ferris JungiD· 1 shared Jennifer HüelleiniD· 1 shared Junyan LuiD· 1 shared Lukas MadenachiD· 1 shared Marcel Fabian PohlyiD· 1 shared Sandra KummeriD· 1 shared Sebastian Scheinost· 1 shared Thi Huong Lan DoiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperSystems Biology

Ferris JungORCID

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2 papers

Recent·Most cited

Systems BiologybioRxivPreprintDec 20, 2025

Cancer pathway connectivity resolved by drug perturbation and RNA sequencing

Thi Huong Lan Do, Caroline Lohoff, Ferris Jung…·Thorsten Zenz

The paper uses drug perturbations and RNA sequencing to map pathway connectivity in CLL, showing how genetic aberrations modulate drug responses and pathway interactions.

DOI 10.64898/2025.12.11.692401

humanbulk RNA-seq

BioinformaticsbioRxivPreprintJun 2, 2022

Bayesian Analysis for 3D combinatorial CRISPR screens

Lukas Madenach, Caroline Lohoff

This paper introduces a Bayesian analysis method for 3D combinatorial CRISPR screens, building on 2D protocols to provide an accessible computational tool.

DOI 10.1101/2022.06.02.494493

CRISPR screenBayesian inference