Structural Basis for the Assembly of Amyloid Fibrils by the Master Cell-Signaling Regulator Human Receptor-Interacting Protein Kinase 1
Paula Polonio, Jorge Pedro López-Alonso, Hanxing Jiang, Fátima C. Escobedo‐González, Gustavo A. Titaux‐Delgado, Iban Ubarretxena‐Belandia, Miguel Mompeán
This study determines the high-resolution structure of human RIPK1 homomeric amyloid fibrils, revealing structural differences from RIPK3 fibrils that inform necroptosis mechanisms.
bioRxiv · Jan 13, 2025 · PreprintBiophysics