The Impact of Breast Cancer Polygenic Risk Score Disclosure on Decisional Conflict Around Risk-Reducing Mastectomy in BRCA1/2 Carriers
Giulia Ongaro, C.M. Salafia, Rania Sheikh, Elizabeth Schofield, Dana Farengo Clark, Jessica Ebrahimzadeh, Anu B. Chittenden, Jill E. Stopfer, Jamie Brower, Heather Symecko, Hannah Ovadia, Alexander Husband, Hadley Barr, Semanti Mukherjee, Jennifer L. Hay, , Jada G. Hamilton
This study examines if disclosing polygenic risk scores reduces decisional conflict in BRCA1/2 carriers considering risk-reducing mastectomy, finding decreased conflict and moderation by tolerance for ambiguity.
medRxiv · Nov 10, 2025 · PreprintGenetic & Genomic Medicine