Early life stress alters lifespan trajectories of amygdala development: a cross-species model of amygdala burnout
Megan Sheppard, Jalil Rasgado‐Toledo, Luis A. Trujillo-Villarreal, Marta Czime Litwińczuk, Katie L. Moran, Elizabeth McManus, Rebecca Elliott, Niall W. Duncan, Eduardo A. Garza‐Villarreal, Tobias Banaschewski, Gareth J. Barker, Arun L.W. Bokde, Rüdiger Brühl, Sylvane Desrivières, Herta Flor, , Nils Muhlert
The paper proposes the amygdala burnout hypothesis, showing early-life stress leads to initial amygdala volume increases in adolescence followed by reductions in older age across rodents and humans.
bioRxiv · Sep 8, 2026 · PreprintNeuroscience