IDH1 regulates human erythropoiesis by eliciting chromatin state reprogramming
Meng‐Jia Li, Hengchao Zhang, Xiuyun Wu, Mengqi Yu, Qianqian Yang, Lei Sun, Wei Li, Zhongxing Jiang, Fumin Xue, Ting Ting Wang, Xiuli An, Lixiang Chen
This study shows that IDH1 deficiency causes chromatin state reprogramming in human erythropoiesis by altering H3K79me3 distribution and upregulating SIRT1, leading to impaired erythropoiesis.
eLife · Aug 5, 2024Peer-reviewedCell Biology