Author

Jacklyn Casanova

Memorial Sloan Kettering Cancer CenterORCID 0000-0002-3586-7048Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:variant calling· 2 Assay:whole-exome sequencing· 2 Approach:deep learning· 1 Approach:statistical model· 1

Frequent Co-Authors

Ahmet ZehiriD· 2 shared Chad VanderbiltiD· 2 shared Gowtham JayakumaraniD· 2 shared Marc LadanyiiD· 2 shared Michael F. BergeriD· 2 shared Ryan N. PtashkiniD· 2 shared Ryma BenayediD· 2 shared Abhinita S. MohantyiD· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenetic & Genomic Medicine

Ahmet ZehirORCID

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2 papers

Recent·Most cited

Enhanced clinical assessment of hematologic malignancies through routine paired tumor:normal sequencing

Ryan N. Ptashkin, Mark David Ewalt, Gowtham Jayakumaran, Iwona J Kiecka, Anita S. Bowman, JinJuan Yao, Jacklyn Casanova, Yun-Te David Lin, Kseniya Petrova‐Drus, Abhinita S. Mohanty, Ruben Bacares, Jamal K. Benhamida, Satshil Rana, Разумова Анна Ивановна, Chad Vanderbilt, , Maria E. Arcila

This study presents a paired tumor:normal sequencing dataset for hematologic malignancies, showing improved identification of somatic variants and their clinical relevance.

medRxiv · Oct 3, 2022 · PreprintGenetic & Genomic Medicine

MiMSI - a deep multiple instance learning framework improves microsatellite instability detection from tumor next-generation sequencing

John Ziegler, Jaclyn Frances Hechtman, Ryan N. Ptashkin, Gowtham Jayakumaran, Sumit Middha, Shweta S. Chavan, Chad Vanderbilt, Deborah F. DeLair, Jacklyn Casanova, Jinru Shia, Nicole DeGroat, Ryma Benayed, Marc Ladanyi, Michael F. Berger, Thomas J. Fuchs, Ahmet Zehir

MiMSI improves MSI detection in low tumor purity samples using deep learning and multiple instance learning, achieving higher sensitivity and auROC than existing methods.

bioRxiv · Sep 16, 2020 · PreprintBioinformatics