From Network Topology to Parameterization: An Optimized Model of Endothelial Mechanobiology
Pete H. Gueldner, Linda Irons, Jeremy L. Warren, David S. Li, Jay D. Humphrey
The paper develops an optimized model of endothelial signaling using ODEs, showing that most responses can be captured with shared parameters, with only a few reactions needing specific parameterization.
bioRxiv · Oct 6, 2026 · PreprintBioengineering