Author

Sima T. Tokajian

Lebanese American UniversityORCID 0000-0002-3653-8940Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:statistical model· 5 Research Focus:variant calling· 3 Assay:whole-genome sequencing· 3 Organism:bacteria (other)· 2 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Organism:E. coli· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

George Farah ArajiD· 4 shared Charbel Al KhouryiD· 3 shared Balig PanossianiD· 2 shared Georgi MerhiiD· 2 shared Leon KassabianiD· 2 shared Anthony HaddadiD· 1 shared Elio IssaiD· 1 shared Ibrahim BitariD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersGenomics

George Farah ArajORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Within-host succession from an OXA-48-like to an NDM-type carbapenemase in clonal ST361 Escherichia coli recovered from sequential urinary and bloodstream infection

Leon Kassabian, Charbel Al Khoury, George Farah Araj, Sima T. Tokajian

The paper describes the within-host succession of carbapenemase types in E. coli isolates from a single patient, showing a shift from OXA-48-like to NDM-type resistance due to plasmid displacement.

bioRxiv · Jul 30, 2026 · PreprintGenomics

Emergence of a novel hypervirulent extensively drug-resistant ST383 Klebsiella pneumoniae lineage carrying ICEKp5 in Lebanon

Martine Abboud, Tia Clara Chaaya, Yara El Daccache, Nour El Alam, Theresa Gerges, Lea Haddad, Leon Kassabian, Jame Tannous, Yara Ghanem, Judy Nabbout, Kevin Chaar, Toni Nmeir, Anthony Haddad, Charbel Al Khoury, George Farah Araj, Sima T. Tokajian

This study identifies a novel hypervirulent extensively drug-resistant ST383 K. pneumoniae lineage in Lebanon carrying ICEKp5 and multiple resistance genes.

bioRxiv · Mar 18, 2026 · PreprintGenomics

Genetic and Structural Basis of Colistin Resistance in Klebsiella pneumoniae: Unraveling the Molecular Mechanisms

Sahar Alousi, Jamal Saad, Balig Panossian, Rita Makhlouf, Charbel Al Khoury, Kelven Rahy, Sergio Thoumi, George Farah Araj, Rony S. Khnayzer, Sima T. Tokajian

This study identifies genetic and structural mechanisms of colistin resistance in Klebsiella pneumoniae, showing mutations and insertion sequences disrupt lipid A modification and regulatory networks.

bioRxiv · Aug 23, 2023 · PreprintGenomics

Whole genome-based characterization of multi-drug resistant Enterobacter and Klebsiella aerogenes isolates from Lebanon

Georgi Merhi, Sara Amayri, Ibrahim Bitar, George Farah Araj, Sima T. Tokajian

This study characterizes multi-drug resistant Enterobacter and Klebsiella aerogenes isolates from Lebanon using whole-genome sequencing, identifying resistance mechanisms and plasmid profiles.

bioRxiv · Jun 17, 2022 · PreprintGenomics

SARS-CoV-2 and ORF3a: Non-Synonymous Mutations and Polyproline Regions

Elio Issa, Georgi Merhi, Balig Panossian, Tamara Salloum, Sima T. Tokajian

The paper analyzes non-synonymous mutations and polyproline regions in ORF3a of SARS-CoV-2 genomes to assess their impact on B-cell epitope formation and immune evasion.

mSystems · May 5, 2020Peer-reviewedGenomics