Quantifying factors that affect polygenic risk score performance across diverse ancestries and age groups for body mass index
Daniel J. Hui, Brenda Xiao, Ozan Dikilitas, Robert R. Freimuth, Marguerite R. Irvin, Gail Pairitz Jarvik, Leah Claire Kottyan, Iftikhar Kullo, Nita A. Limdi, Cong Liu, Yuan Luo, Bahram Namjou, Megan J. Puckelwartz, Daniel J. Schaid, Hemant K. Tiwari, , Marylyn DeRiggi Ritchie
This study evaluates how ancestry, GWAS sample size, and LD reference panels affect BMI PRS performance across different age groups and ancestries.
Pacific Symposium on Biocomputing (PSB) · Nov 1, 2022Peer-reviewedGenetic & Genomic Medicine