Author

Yiwei Lyu

University of MichiganORCID 0000-0002-3882-4246Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:benchmark study· 1 Research Focus:cell type annotation· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Andrew Robbins· 1 shared Ming-Ching Crystal Wen· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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2 top collaborators · 1 mutual co-author link

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1 shared paperBioinformatics

Andrew Robbins

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1 paper

Recent·Most cited

Beyond the Final Layer: Evaluating Single-Cell Foundation Model Representations for Molecular Prediction

Ming-Ching Crystal Wen, Yiwei Lyu, Andrew Robbins

This paper evaluates the performance of intermediate layers in single-cell foundation models for cell-type and perturbation prediction, finding that some layers perform as well as final layers.

bioRxiv · Oct 12, 2026 · PreprintBioinformatics