Microthrombi-growth in ADAMTS13 deficiency exacerbated ulcerative colitis via mucosal and endothelial dysfunction
Kyota Tatsuta, Naoki Honkura, Nanami Morooka, Mayu Sakata, Kiyotaka Kurachi, Ken Sugimoto, Koichi Kokame, Hiroya Takeuchi, Tetsumei Urano, Yuko Suzuki
This study shows ADAMTS13 deficiency worsens ulcerative colitis by promoting microthrombi formation, mucosal damage, and endothelial dysfunction, with intravital imaging revealing these mechanisms at single-cell resolution.
Journal of Thrombosis and Haemostasis · Oct 18, 2025Peer-reviewedPhysiology