Reduction of a stochastic model of gene expression: Lagrangian dynamics gives acces to basins of attraction as cell types and metastability
Elias Ventre, Thibault Espinasse, Charles-Édouard Bréhier, Vincent Calvez, Thomas Lepoutre, Olivier Gandrillon
The paper reduces a stochastic gene expression model to a discrete coarse-grained model, using Lagrangian dynamics to identify basins of attraction as cell types and calculate metastability.
Journal of Mathematical Biology · Nov 1, 2021Peer-reviewedSystems Biology