Elli-Mari Aska

Single-cell sequencing of mouse thymocytes reveals mutational landscape shaped by replication errors, mismatch repair and H3K36me3

The paper uses single-cell exome sequencing to study how replication errors, H3K36me3, and MMR shape the mutational landscape in mouse thymocytes.

Mlh1 haploinsufficiency induces microsatellite instability specifically in intestine

This study shows that Mlh1 haploinsufficiency causes microsatellite instability specifically in the intestine, not in the spleen, before tumorigenesis.