Explainable machine learning identifies features and thresholds predictive of immunotherapy response
Khoa Anh Tran, Venkateswar Addala, Lambros T. Koufariotis, Jia Zhang, Scott Wood, Conrad Leonard, Lotte L. Hoeijmakers, Christian U. Blank, Mireia Crispin‐Ortuzar, Elizabeth D. Williams, Olga Kondrashova, John V. Pearson, Nicola Waddell
The paper develops a multi-omic random forest model to predict immunotherapy response in melanoma using SHAP for feature threshold identification.
Scientific Reports · May 23, 2026Peer-reviewedBioinformatics