The Amplified Burden of Depression in Drug-Resistant Epilepsy: Role of Limbic Network Dynamic Reconfiguration
Zhoukang Wu, Haiyun Tang, Liangjiecheng Huang, Min Wang, Yaotian Gao, Aobo Chen, Hang Cao, Yuzhuo Gong, Jia Ming Hu, Xiaoping Yi, Xiaosong He
The paper investigates how drug resistance in temporal lobe epilepsy is linked to limbic network dysfunction and depression, finding that reduced network integration correlates with depressive symptoms and specific neurochemical and transcriptomic changes.
bioRxiv · Jul 20, 2025 · PreprintNeuroscience