Distribution-Constrained Optimization for Reliable ML-Guided 5'UTR Sequence Design
Ryohei Yamaguchi, Chinatsu Mori, Sota Inoue
This paper introduces a constrained optimization method for designing 5'UTR sequences using deep learning models, ensuring candidates stay within a trust region defined by an OOD score based on KNN distance.
bioRxiv · Aug 7, 2026 · PreprintBioinformatics