CausalCellInfer: Resolving cell-type-specific disease mechanisms from biobank-scale GWAS
Liangying Yin, Yujia Shi, Ruoyu Zhang, Yong Xiang, Jinghong Qiu, Pak Chung Sham, Hon‐Cheong So
CausalCellInfer integrates single-cell RNA-seq with biobank-scale GWAS to identify cell-type-specific disease mechanisms, revealing known and novel biological signals in traits like Type 2 Diabetes and depression.
medRxiv · Oct 17, 2024 · PreprintGenetic & Genomic Medicine