Mitotic CDK4/6 activity sustains spindle checkpoint signalling to prevent mitotic slippage and genomic instability
Zhaoru Zhang, Yang Li, Maïté Leturcq, Yusanjiang Abula, Xinyue Wu, Yuu Kimata
This study shows CDK4/6 sustains spindle checkpoint signalling to prevent mitotic slippage and genomic instability by phosphorylating SAC regulators like CENP-E.
bioRxiv · Sep 13, 2025 · PreprintCell Biology