Metabolic Dysfunction Underlying Fatigue in Multiple Sclerosis: Elevated Lactate and Impaired Post-Exercise Creatine Response in the Anterior Cingulate Cortex
Gemma Brownbill, Jeanne Dekerle, Mara Cercignani, Itamar Ronen, James M. Stone
This study finds elevated lactate and stable post-exercise creatine in MS patients' anterior cingulate cortex, suggesting altered energy metabolism linked to mitochondrial dysfunction.
bioRxiv · Nov 6, 2025 · PreprintNeuroscience