Resolving Local and Global Conformational Heterogeneity of the Human Intrinsically Disordered Proteome
Hossain Shadman, Jesse Dylan Ziebarth, Qianyi Cheng, Mohamed Laradji, Yongmei Wang
This paper introduces a framework to resolve conformational heterogeneity in human intrinsically disordered regions (IDRs) using polymer physics descriptors, revealing local and global structural differences linked to function.
Journal of Chemical Theory and Computation · Jun 29, 2026Peer-reviewedBiochemistry