Author

Jeffrey Negrea

University of WaterlooORCID 0000-0002-4665-3571Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1

Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Approach:statistical model· 1

Frequent Co-Authors

Coby VineriD· 1 shared Danielle DeniskoiD· 1 shared Lei SuniD· 1 shared Lin ZhangiD· 1 shared Michael M. HoffmaniD· 1 shared Scott MastromatteoiD· 1 shared Yanbo TangiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperBioinformatics

Coby VinerORCID

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1 paper

Recent·Most cited

Beyond statistical significance: ranking transcription factor binding motifs by effect size

Coby Viner, Scott Mastromatteo, Danielle Denisko, Jeffrey Negrea, Yanbo Tang, Lin Zhang, Michael M. Hoffman, Lei Sun

The paper introduces effect size-based methods to rank transcription factor binding motifs, showing they outperform p-value rankings under heterogeneous sample sizes.

bioRxiv · Jun 24, 2026 · PreprintBioinformatics