PaIRKAT: A pathway integrated regression-based kernel association test with applications to metabolomics and COPD phenotypes
Charlie M. Carpenter, Weiming Zhang, Lucas A. Gillenwater, Cameron Severn, Tusharkanti Ghosh, Russell Paul Bowler, Katerina J. Kechris, Debashis Ghosh
PaIRKAT improves testing power for pathway-phenotype associations by integrating graph structure into kernel regression, showing effectiveness in metabolomics data.
PLoS Computational Biology · Oct 22, 2021Peer-reviewedBioinformatics