Deviation from mendelian transmission of autosomal SNPs can be used to estimate germline mutations in humans exposed to ionizing radiation
Hugo Pereira Leite Filho, Irene Plaza Pinto, Lorraynne Guimarães Oliveira, Emília Costa, Alex Silva da Cruz, Daniela de Melo e Silva, Cláudio Carlos da Silva, Alexandre Rodrigues Caetano, Aparecido Divino da Cruz
The paper estimates germline mutation rates in offspring of radiation-exposed individuals using Mendelian deviation analysis and finds increased de novo mutations in exposed groups.
PLoS ONE · Oct 27, 2020Peer-reviewedGenetics