Author

Sheila Iyer

Johns Hopkins UniversityORCID 0000-0002-4846-1506Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

Ben LangmeadiD· 2 shared Nae-Chyun CheniD· 2 shared Brad SolomoniD· 1 shared Mao-Jan LiniD· 1 shared Taher MuniD· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

5 top collaborators · 8 mutual co-author links

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2 shared papersBioinformatics

Ben LangmeadORCID

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2 papers

Recent·Most cited

Measuring, visualizing and diagnosing reference bias with biastools

Mao-Jan Lin, Sheila Iyer, Nae-Chyun Chen, Ben Langmead

The paper introduces biastools to measure and diagnose reference bias in genomic data across different scenarios and finds that inclusive graph genomes and end-to-end alignment reduce bias.

Genome biology · Apr 19, 2024Peer-reviewedBioinformatics

Reducing reference bias using multiple population reference genomes

Nae-Chyun Chen, Brad Solomon, Taher Mun, Sheila Iyer, Ben Langmead

The paper introduces a reference flow alignment method that reduces reference bias using multiple population reference genomes, achieving similar accuracy to graph aligners with lower memory usage and faster speed.

Genome biology · Jan 4, 2021Peer-reviewedBioinformatics