Homology-Based Variant-Effect Predictors Break Down on Cytochrome P450 Pharmacogenes
Helen Z. Xu, Issah Samori, Gowri Nayar, Russ Biagio Altman
The paper shows homology-based variant-effect predictors fail for CYP enzymes and proposes an improved model that still lacks clinical relevance.
bioRxiv · Oct 2, 2026 · PreprintBioinformatics