Author

Marc D. Ryser

Duke UniversityORCID 0000-0002-4990-0849Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Daniel L. MonyakiD· 2 shared Darryl K. ShibataiD· 2 shared Graham J. Gumbert· 2 shared Jeffrey R. MarksiD· 2 shared Lars J. GrimmiD· 2 shared Shannon T. HollowayiD· 2 shared Allison Fong· 1 shared E. Shelley HwangiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 34 mutual co-author links

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2 shared papersCancer Biology

Daniel L. MonyakORCID

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2 papers

Recent·Most cited

Aggressive Neuroblastomas Start Growing after Infancy

Daniel L. Monyak, Shannon T. Holloway, Graham J. Gumbert, K.Anthony Kim, Allison Fong, Lars J. Grimm, Jeffrey R. Marks, Darryl K. Shibata, Marc D. Ryser

This study estimates tumor mitotic ages in neuroblastoma patients to show aggressive tumors start growing after infancy, making them undetectable by infant screening.

bioRxiv · Mar 13, 2026 · PreprintCancer Biology

Mapping the Temporal Landscape of Breast Cancer Using Epigenetic Entropy

Daniel L. Monyak, Shannon T. Holloway, Graham J. Gumbert, Lars J. Grimm, E. Shelley Hwang, Jeffrey R. Marks, Darryl K. Shibata, Marc D. Ryser

This paper estimates the age of breast cancers using an epigenetic clock based on methylation data, finding that younger tumors are more aggressive while older tumors show higher immune infiltration.

Communications Biology · Oct 16, 2025Peer-reviewedCancer Biology