Author

Ramakrishnan Rajagopalan

Children's Hospital of PhiladelphiaORCID 0000-0002-5028-1010Unclaimed ORCID profile · follow to get notified of new preprints

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Ramakrishnan Rajagopalan2 papers · Children's Hospital of Philadelphia

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Evolutionary Biology· 1

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Research Focus:benchmarking· 1 Approach:deep learning· 1 Research Focus:gene regulatory network inference· 1 Assay:GWAS summary statistics· 1 Organism:human· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Andrew S. AlleniD· 1 shared Christopher J. SottolanoiD· 1 shared Constantine StavrianidisiD· 1 shared Grace E. RhodesiD· 1 shared Grace Tzun-Wen ShawiD· 1 shared Tanaya JadhaviD· 1 shared Tristan J. HayeckiD· 1 shared Yuncheng DuaniD· 1 shared

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2025-2025 · peak 1/yr

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8 top collaborators · 28 mutual co-author links

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1 shared paperEvolutionary Biology

Andrew S. AllenORCID

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1 paper

Recent·Most cited

Functional Category-Specific Intolerance Reflects Genic Function and Clinical Relevance

Yuncheng Duan, Constantine Stavrianidis, Grace Tzun-Wen Shaw, Christopher J. Sottolano, Ramakrishnan Rajagopalan, Tanaya Jadhav, Grace E. Rhodes, Tristan J. Hayeck, Andrew S. Allen

This paper introduces CATMINT, a method to estimate gene-level intolerance across variant categories, showing it outperforms existing metrics and reveals category-specific intolerance patterns in disease genes.

bioRxiv · Sep 24, 2025 · PreprintEvolutionary Biology