Hyper-connectivity between the left motor cortex and prefrontal cortex is associated with the severity of dysfunction of the descending pain modulatory system in fibromyalgia
Álvaro de Oliveira Franco, Camila Fernanda da Silveira Alves, Paul Vicuña Serrano, Janete Shatkoski Bandeira, Maria Adelia Aratanha, Iraci Lucena da Silva Torres, Felipe Fregni, Wolnei Caumo
This study finds that fibromyalgia patients who do not respond to pain modulation tests show increased functional connectivity between the left motor cortex and prefrontal cortices, suggesting a neural marker of pain system dysfunction.
PLoS ONE · May 27, 2022Peer-reviewedNeuroscience