FORGEPHAST: A fast, haplotype-first complex population and phenotype simulator for biobank-scale simulation
Hersh V. Gupta, Srilakshmi M. Raj
FORGEPHAST simulates large synthetic cohorts with controlled genetic and phenotypic properties, showing polygenic risk score performance varies by phenotype architecture, ancestry, and variant coverage.
bioRxiv · Aug 4, 2026 · PreprintGenomics