Author

Yongkai Chen

Harvard UniversityORCID 0000-0002-5243-8341Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Yongkai Chen1 paper · University of Georgia

Biology Disciplines

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Biochemistry· 1 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Approach:diffusion model· 1 Research Focus:dimensionality reduction· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Research Focus:spatial domain detection· 1 Assay:spatial transcriptomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Guo‐Cheng YuaniD· 1 shared Jiazhang CaiiD· 1 shared Luyang FangiD· 1 shared Ping MaiD· 1 shared Sameul Kou· 1 shared Samuel W. K. WongiD· 1 shared Wenxuan ZhongiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 11 mutual co-author links

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1 shared paperBioinformatics

Guo‐Cheng YuanORCID

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2 papers

Recent·Most cited

Uncovering distinct protein conformations using coevolutionary information and AlphaFold

Yongkai Chen, Samuel W. K. Wong, Sameul Kou

This work introduces an iterative sampling framework using coevolutionary information and AlphaFold to improve the diversity of sampled protein conformations.

bioRxiv · Oct 8, 2025 · PreprintBiochemistry

SpaDiff: Denoising for Sequence-based Spatial Transcriptomics via Diffusion Process

Jiazhang Cai, Yongkai Chen, Luyang Fang, Wenxuan Zhong, Guo‐Cheng Yuan, Ping Ma

SpaDiff improves spatial transcriptomics by reversing RNA molecule displacement, enhancing spatial specificity and data integrity for downstream analyses.

bioRxiv · Oct 7, 2025 · PreprintBioinformatics