Tying the Knot: In Silico Design of Foldable Lasso Peptides
John D. M. Nguyen, Gabriel C. A. da Hora, Marcus C. Mifflin, Andrew G. Roberts, Jessica M. J. Swanson
This paper designs foldable lasso peptides through sequence optimization and chemical modifications, showing improved pre-lasso stability and demonstrating cooperative benefits of cross-linking with modifications.
bioRxiv · Jan 17, 2025 · PreprintBiophysics