Author

Matěj Špeťko

VSB - Technical University of OstravaORCID 0000-0002-5486-0503Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Approach:diffusion model· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Research Focus:sequence-to-function modeling· 1 Research Focus:software / tool· 1 Approach:statistical model· 1

Frequent Co-Authors

Aakarsh Vermani· 1 shared Ellena Jiang· 1 shared Minji LeeiD· 1 shared Mohammed AlQuraishiiD· 1 shared Sebastiaan De Cooman· 1 shared Yi‐Cheng LiniD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 15 mutual co-author links

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1 shared paperBioinformatics

Aakarsh Vermani

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1 paper

Recent·Most cited

Fast and Ultra-Capable Protein Design: Advancing the Frontier Through Atomistic SE(3)-Equivariance with Genie 3

Yi‐Cheng Lin, Minji Lee, Aakarsh Vermani, Ellena Jiang, Sebastiaan De Cooman, Matěj Špeťko, Mohammed AlQuraishi

This paper introduces Genie 3, a diffusion model that improves protein design by combining SE(3)-equivariance with hallucination, achieving state-of-the-art results in binder design and motif scaffolding.

bioRxiv · May 5, 2026 · PreprintBioinformatics