Travers H. Ching

Using Single Nucleotide Variations in Single-Cell RNA-Seq to Identify Subpopulations and Genotype-phenotype Linkage

The paper introduces SSrGE, a method using SNVs from scRNA-seq to identify subpopulations and link genotype-phenotype relationships, showing better accuracy than gene expression.

Multi-modal meta-analysis of 1494 hepatocellular carcinoma samples reveals vast impacts of consensus driver genes on phenotypes

This study identifies 10 consensus driver genes in HCC across six cohorts and shows their associations with mRNA transcriptomes, patient survival, and demographic factors.

Opportunities And Obstacles For Deep Learning In Biology And Medicine

Deep learning rivals or beats baselines across imaging, health records, genomics and drug discovery but is not yet transformative; scarce labels, privacy and opacity remain hurdles.