Xinyi Du-Harpur

The paper builds a spatiotemporal map of human pilosebaceous unit development using single-cell multiomics and machine learning, showing how epithelial-mesenchymal interactions drive organogenesis and how sebaceous gland programs are disrupted in tumors.

This study uses single-cell RNA-sequencing and spatial transcriptomics to characterize keratinocyte states and fibroblast niches in severe HS lesions, revealing spatially distinct interactions that may explain treatment resistance.

The paper examines CD147 and ACE2 expression in vascular endothelial cells using single-cell RNA sequencing data from multiple tissues, finding CD147 detectable while ACE2 is not.