Zong Miao

Enhancing droplet-based single-nucleus RNA-seq resolution using the semi-supervised machine learning classifier DIEM

The paper introduces DIEM, a semi-supervised machine learning classifier to remove debris-contaminated droplets in snRNA-seq, improving clustering quality across three datasets.

Accurate estimation of cell composition in bulk expression through robust integration of single-cell information

Bisque estimates cell composition in bulk RNA-seq using single-cell data, improving accuracy and efficiency over existing methods.

Phenotype-specific enrichment of Mendelian disorder genes near GWAS regions across 62 complex traits

The paper quantifies the overlap between GWAS genes for 62 complex traits and Mendelian disorder genes, finding significant enrichment and elevated effect sizes for phenotypically-matched genes.