Conservation of non-consensus nucleotides in transcription factor binding sites
Jenya Belousova, Roberto Morán-Tovar, Malancha Karmakar, Mikhail Sergeevich Gelfand
The paper shows that non-consensus nucleotides in transcription factor binding sites can be conserved due to epistatic interactions with other nucleotides in the same site.
bioRxiv · Jan 13, 2026 · PreprintBioinformatics