Eric D. Ross

A composition-matching algorithm, MatchIDR, identifies prion-like domains that localize to stress granules

MatchIDR identifies prion-like domains that localize to stress granules by finding compositional matches in proteomes.

Identification of Low-Complexity Domains by Compositional Signatures Reveals Class-Specific Frequencies and Functions Across Reference Proteomes

The paper identifies low-complexity domains (LCDs) across reference proteomes, revealing class-specific frequencies and functions, with many LCDs being eukaryote-specific.

Atypical Structural Tendencies Among Low-Complexity Domains in the Protein Data Bank Proteome

The paper examines how the secondary structure preferences of low-complexity domains (LCDs) vary based on amino acid composition and enrichment, revealing distinct structural tendencies among LCDs with similar physicochemical properties.

Natural and Pathogenic Protein Sequence Variation Affecting Prion-Like Domains Within and Across Human Proteomes

The paper examines how sequence variation in prion-like domains (PrLDs) affects aggregation propensity in human proteins, identifying mutations linked to increased aggregation and disease.

Proteome-Scale Relationships Between Local Amino Acid Composition and Protein Fates and Functions

The paper investigates how local amino acid composition influences protein metabolism, localization, and function across the proteome, revealing distinct effects based on amino acid type.